Phenotypic, agronomic and ecological interactions evaluations indicate that MON 531 x MON 1445 cotton is comparable to conventional cotton and does not have a greater risk of becoming an invasive plant. 6. the CP4 EPSPS protein is rapidly degraded in the gastrointestinal system of humans and animals; in addition, its mode of action, specificity and the absence of homology with toxic sequences makes this protein not pose a risk to human health or the environment. laboratory studies with indicator species have shown that CrylAc protein does not cause adverse effects on non-target organisms. in studies evaluating the potential for allergenicity, it was proved that CP4 EPSPS and NPTII proteins are not detectable in cotton products used as human and animal food, and do not pose a significant risk; the evaluations of the phenotypic and agronomic characteristics of Cotton Roundup Ready event 1445 carried out in Brazil showed results similar to those found in other regions of the world in experimental and commercial planting.